| Player | From | Fee | Date | |
|---|---|---|---|---|
 | Emiliano Buendia | Norwich | £34,500,000 | 10-Jun-21 |
 | Ashley Young | Inter Milan | Free | 17-Jun-21 |
| Josh Feeney | Fleetwood | Undisc. | 06-Jul-21 |
 | Ajani Burchall | Bournemouth | Undisc. | 09-Jul-21 |
| Finn Azaz | West Brom | Undisc. | 25-Jul-21 |
| Tim Iroegbunam | West Brom | Undisc. | 29-Jul-21 |
 | Leon Bailey | Bayer Leverkusen | £28,800,000 | 04-Aug-21 |
| Danny Ings | Southampton | £31,500,000 | 04-Aug-21 |
| Axel Tuanzebe | Man. Utd | Loan | 08-Aug-21 |
| Caleb Chukwuemeka | Northampton | Undisc. | 16-Aug-21 |
 | Philippe Coutinho | Barcelona | Loan | 07-Jan-22 |
 | Lucas Digne | Everton | £27,000,000 | 12-Jan-22 |
 | Kerr Smith | Dundee Utd | Undisc. | 14-Jan-22 |
 | Robin Olsen | AS Roma | Loan | 18-Jan-22 |
| Calum Chambers | Arsenal | Free | 27-Jan-22 |
| Player | To | Fee | Date | |
|---|---|---|---|---|
| Callum Row | Exeter | Free | 28-Jun-21 |
| Tom Heaton | Man. Utd | Free | 01-Jul-21 |
 | Lovre Kalinic | Hadjuk Split | Loan | 01-Jul-21 |
 | Neil Taylor | Released | 01-Jul-21 | |
| Jake Walker | Released | 01-Jul-21 | |
| Michael Tait | Released | 01-Jul-21 | |
 | Ahmed Elmohamady | Released | 01-Jul-21 | |
 | Mbwana Samatta | Fenerbahce | Undisc. | 03-Jul-21 |
 | Indiana Vassilev | Inter Miami CF | Loan | 07-Jul-21 |
 | Bjorn Engels | Royal Antwerp | £6,900,000 | 18-Jul-21 |
| Finn Azaz | Newport Co. | Loan | 26-Jul-21 |
| Sebastian Revan | Grimsby | Loan | 28-Jul-21 |
| Kaine Kesler Hayden | Swindon | Loan | 02-Aug-21 |
| Jack Grealish | Man. City | £100,000,000 | 05-Aug-21 |
| Louie Barry | Ipswich | Loan | 05-Aug-21 |
| Brad Young | Carlisle | Loan | 16-Aug-21 |
 | Tyreik Wright | Salford City | Loan | 17-Aug-21 |
| Arjan Raikhy | Stockport Co. | Loan | 20-Aug-21 |
| Wesley | Club Brugge | Loan | 28-Aug-21 |
| Conor Hourihane | Sheff Utd | Loan | 30-Aug-21 |
| Dominic Revan | Northampton | Loan | 31-Aug-21 |
| Mungo Bridge | FC Annecy | Loan | 31-Aug-21 |
| Frederic Guilbert | Strasbourg | Loan | 31-Aug-21 |
| Keinan Davis | Notts. For | Loan | 01-Jan-22 |
| Wesley | Internacional | Loan | 06-Jan-22 |
| Aaron Ramsey | Cheltenham | Loan | 11-Jan-22 |
| Caleb Chukwuemeka | Livingston | Loan | 12-Jan-22 |
 | Anwar El Ghazi | Everton | Loan | 13-Jan-22 |
| Sebastian Revan | Hereford | Loan | 14-Jan-22 |
| Arjan Raikhy | Grimsby | Loan | 15-Jan-22 |
| Jaden Philogene-Bidace | Stoke | Loan | 21-Jan-22 |
| Cameron Archer | Preston | Loan | 24-Jan-22 |
| Louie Barry | Swindon | Loan | 28-Jan-22 |
 | Filip Marschall | Gateshead | Loan | 31-Jan-22 |
| Jed Steer | Luton | Loan | 31-Jan-22 |
| Matt Targett | Newcastle | Loan | 31-Jan-22 |
| Kaine Kesler Hayden | MK Dons | Loan | 31-Jan-22 |
| Tyreik Wright | Colchester | Loan | 31-Jan-22 |
| Trezeguet | Basaksehir | Loan | 08-Feb-22 |